inaboannax.blogg.se - Rapid diagnostic test for malaria

Of the 10 studies, six used microscopy, one used PCR, two used both microscopy and PCR separately and one used microscopy corrected by PCR as the reference standard. One study directly compared the accuracy of two RDT brands. We included 10 studies that assessed the accuracy of six different RDT brands (CareStart Malaria Pf/Pv Combo test, Falcivax Device Rapid test, Immuno-Rapid Malaria Pf/Pv test, SD Bioline Malaria Ag Pf/Pv test, OnSite Pf/Pv test and Test Malaria Pf/Pv rapid test) for detecting P vivax malaria. The review authors searched for studies published up to 30 July 2019. Some studies did not report clearly how common P malaria was in the area where the study was done. Some rapid antibody tests were investigated by only one study. Most studies included in this review had limitations: it was not clear how people were selected for testing, or how the study results were assessed and checked, which could have affected the results. Our results are based on a small number of studies, so we could not reliably assess all six brands of antibody test or compare their accuracy. Our findings for this test will probably change when results from further studies become available. We are less confident in the accuracy results for the Falcivax Device Rapid test, because these came from only two studies. The results are from a small number of studies (four), so our findings may change when results from further studies become available.

We are moderately confident (certain) in the accuracy results for the Care Start Malaria Pf/Pv Combo test.

for every 100 people tested who do not have P vivax malaria, one person will have a positive result.

For every 100 people tested who have P vivax malaria, 23 people will have a negative test result and,.

for every 100 people tested who do not have P vivax malaria, one will have a positive result, and might receive unnecessary treatment.Ĭompared with microscopy, the Falcivax Device Rapid test had a sensitivity of 77% and a specificity of 99% (two studies).

for every 100 people tested who have P vivax malaria, one person will have a negative test result, and might not receive the right treatment soon enough.

The studies were conducted in Ethiopia (four studies), India (two studies) and Bangladesh, Brazil, Colombia, and Sudan (one study each).Ĭompared with microscopy, the Care Start Malaria Pf/Pv Combo test performed well with 99% sensitivity and specificity (four studies). We included 10 studies that looked at the accuracy of six diagnostic test brands for detecting P vivax malaria in people with suspected malaria symptoms. We compared the new tests against the standard form of diagnosis with microscopy, and also more recent methods polymerase chain reaction (PCR): a molecular method to identify P vivax DNA in blood samples. We wanted to find out which brands of RDTs were the most accurate for diagnosing P vivax malaria. Healthcare workers in rural areas can perform RDTs for P vivax without needing a laboratory or special equipment. They are suitable for use in rural settings by primary healthcare workers, using drop of blood on the dipstick that causes colour change and a distinct line that indicates a positive test result. RDTs are simple to use, point-of-care tests. We studied RDTs that specifically test for P vivax malaria.

RDTs provide results quickly and are often as a dipstick. For public health control of malaria, we know that P falciparum is declining over the previous 15 years, and infections from P vivax have therefore increased in importance. For P vivax infection, an additional drug is required to eliminate the infection from the liver. Why are rapid tests for P vivax malaria important?įor clinical management, knowing which parasite species is causing the malaria is important as the drug treatments differ. The aim of this review was to evaluate rapid diagnostic tests (RDTs) to diagnose P vivax infection. Malaria infection is caused mainly by two species of malaria parasite: Plasmodium falciparum and Plasmodium vivax.